Seasonal influenza is a common and highly contagious respiratory infection that is usually caused by influenza A or B viruses, with numerous subtypes and strains associated with this disease. Infection with seasonal influenza A or B viruses can result in mild to severe illness and seasonal influenza vaccines offer the best protection against developing severe illness. In addition to seasonal influenza A virus (IAV), numerous subtypes of avian IAV cause occasional, often severe infections in humans, noting that little evidence of person-to-person transmission of avian IAVs has been reported to date. Since 2021, highly pathogenic avian influenza (HPAI) H5N1 viruses of clade 2.3. 4.4b have caused significant illness and deaths in wild birds, mammals (both wild and domestic) and poultry in all geographical regions except Oceania. In 2024, these viruses were also detected in dairy cattle in the USA, resulting in an ongoing multistate outbreak, with high levels of virus secreted into raw milk derived from infected animals. Human infections with clade 2.3.4.4b viruses from exposures to infected poultry or dairy cattle have also been reported. In addition, other clades of H5N1 viruses and other avian subtypes continue to cause sporadic, often severe infections in humans. This presentation will provide an overview of the current global influenza situation, addressing current seasonal influenza virus infections, as well as zoonotic virus infections that continue to pose a threat to the human population.