Science Bite (3 minute oral presentation with PPT in live session and poster) - Students, ECRs and EMCRs only 15th Lorne Infection and Immunity 2025

Antibody-dependent serum resistance protects bacteria in chronic wound infections (#312)

Michelle N Chamoun 1 , Gabriela Gonzalez Matheus 1 2 , Yogeesan Sivakumaran 3 4 , Kiarash Khosrotehrani 1 2 , Timothy Wells 1
  1. Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia
  2. Department of Dermatology, Princess Alexandra Hospital, Woolloongabba, QLD, Australia
  3. Faculty of Medicine, The University of Queensland, Herston, QLD, Australia
  4. Department of Vascular Surgery, Princess Alexandra Hospital, Woolloongabba, QLD, Australia
Publish consent withheld
  1. 1: Serra R, Grande R, Butrico L, Rossi A, Settimio UF, Caroleo B, Amato B, Gallelli L, De Franciscis S. Chronic wound infections: the role of Pseudomonas aeruginosa and Staphylococcus aureus. Expert review of anti-infective therapy. 2015 May 4;13(5):605-13.
  2. 2: Mikucionyte G, Dambrauskiene A, Skrodeniene E, Vitkauskiene A. Biofilm formation and serum susceptibility in Pseudomonas aeruginosa. Central European Journal of Medicine. 2014 Apr;9:187-92.
  3. 3: Wells TJ, Whitters D, Sevastsyanovich YR, Heath JN, Pravin J, Goodall M, Browning DF, O’Shea MK, Cranston A, De Soyza A, Cunningham AF. Increased severity of respiratory infections associated with elevated anti-LPS IgG2 which inhibits serum bactericidal killing. Journal of Experimental Medicine. 2014 Aug 25;211(9):1893-904.
  4. 4: Hickson SM, Hoehensteiger JK, Mayer-Coverdale J, Torres VV, Feng W, Monteith JN, Henderson IR, McCarthy KL, Wells TJ. Antibody-Mediated Serum Resistance Protects Pseudomonas aeruginosa During Bloodstream Infections. The Journal of Infectious Diseases. 2024 Jan 17:jiad457
  5. 5: Wells TJ, Esposito T, Henderson IR, Labzin LI. Mechanisms of antibody-dependent enhancement of infectious disease. Nature Reviews Immunology. 2024 Aug 9:1-6.